Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes

  title={Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes},
  author={Will McLean and C. Pekiner and Nicola A. Cullum and Ian F. Casson},
  journal={Molecular Neurobiology},
Axonal transport is known to be impaired in peripheral nerve of experimentally diabetic rats. As axonal transport is dependent on the integrity of the neuronal cytoskeleton, we have studied the way in which rat brain and nerve cytoskeletal proteins are altered in experimental diabetes. Rats were made diabetic by injection of streptozotocin (STZ). Up to six weeks later, sciatic nerves, spinal cords, and brains were removed and used to prepare neurofilaments, microtubules, and a crude preparation… CONTINUE READING
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