Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes

@article{McLean1992PosttranslationalMO,
  title={Posttranslational modifications of nerve cytoskeletal proteins in experimental diabetes},
  author={Will McLean and C. Pekiner and Nicola A. Cullum and Ian F. Casson},
  journal={Molecular Neurobiology},
  year={1992},
  volume={6},
  pages={225-237}
}
Axonal transport is known to be impaired in peripheral nerve of experimentally diabetic rats. As axonal transport is dependent on the integrity of the neuronal cytoskeleton, we have studied the way in which rat brain and nerve cytoskeletal proteins are altered in experimental diabetes. Rats were made diabetic by injection of streptozotocin (STZ). Up to six weeks later, sciatic nerves, spinal cords, and brains were removed and used to prepare neurofilaments, microtubules, and a crude preparation… CONTINUE READING
11 Citations
64 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 11 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 64 references

Neurofilament phosphorylation in spinal cord of experimentally diabetic rats

  • C. Pekiner, W G.McLean
  • J. Neurochem
  • 1991

Phos - phorylation of bovine neurofilament proteins by protein kinase F A ( glycogen synthase kinase 3 )

  • J. GuanR., S. KhatraB., A. CohlbergJ.
  • J . Biol . Chem .
  • 1991

Phosphorylation of the amino-terminal head domain of the middle molecular mass 145kDa subunit of neurofilaments

  • R K.Sihag, R A.Nixon
  • J. Biol
  • 1990

Effect of a single dose of iminodipropionitrile in vivo on the properties of neurofilaments in vitro: comparison with the effect of iminodipropionitrile added directly to neurofilaments in vitro

  • J. Eyer, W G.McLean, J F.Leterrier
  • J. Neur0chem
  • 1989
2 Excerpts

Similar Papers

Loading similar papers…