Posttranslational modification of glycine‐extended substance P by an α‐amidating enzyme in cultured sensory neurons of dorsal root ganglia

@article{Wong1994PosttranslationalMO,
  title={Posttranslational modification of glycine‐extended substance P by an α‐amidating enzyme in cultured sensory neurons of dorsal root ganglia},
  author={M. Wong and A. Jeng},
  journal={Journal of Neuroscience Research},
  year={1994},
  volume={37}
}
  • M. Wong, A. Jeng
  • Published 1994
  • Chemistry, Medicine
  • Journal of Neuroscience Research
The terminal step in the biosynthesis of substance P is the conversion of its glycine‐extended precursor to the mature, amidated peptide by the α‐amidating enzyme. This posttranslational modification was demonstrated in cultured dissociated sensory neurons of dorsal root ganglia from neonatal rats. An assay was developed to quantitate both substance P and its precursor peptide in these cells. More than 90% of these two peptide was present as mature peptide in uncultured cells. In contrast… Expand
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References

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