Posttranslational modification of class III beta-tubulin.

  title={Posttranslational modification of class III beta-tubulin.},
  author={Matt K Lee and Lionel I. Rebhun and Anthony Frankfurter},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={87 18},
The charge heterogeneity of class III beta-tubulin (beta III) during neural development was analyzed by high-resolution isoelectric focusing/two-dimensional polyacrylamide gel electrophoresis in combination with site-specific proteolytic digestion and immunological detection. The number of beta III isoforms (charge variants) gradually increases from one in embryonic brain to seven in adult brain. All of the charge heterogeneity is due to posttranslationally modified sites located within the… CONTINUE READING
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