Posttranslational modification of MDM2.

  title={Posttranslational modification of MDM2.},
  author={D. W. 5303 Meek and Uwe Knippschild},
  journal={Molecular cancer research : MCR},
  volume={1 14},
The functions of the MDM2 protein, in particular its E3 ubiquitin ligase activity and its ability to interact with a number of cellular proteins intimately involved in growth regulation, are modulated by sumoylation and multisite phosphorylation. These posttranslational mechanisms not only regulate the intrinsic activity of MDM2 in response to cellular stresses, but also govern its subcellular localization, differentiate between MDM2-mediated ubiquitination of p53 and autoubiquitination… CONTINUE READING


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