Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes.

  title={Posttranslational modification of HLA-DQ binding islet autoantigens in type 1 diabetes.},
  author={Menno van Lummel and Gaby Duinkerken and Peter A. van Veelen and Arnoud de Ru and Robert A. Cordfunke and Arnaud Zaldumbide and Iria Maria Gomez-Touri{\~n}o and Sefina Arif and Mark Peakman and Jan Wouter Drijfhout and Bart O Roep},
  volume={63 1},
Posttranslational modification (PTM) of islet autoantigens can cause lack of central tolerance in type 1 diabetes (T1D). Tissue transglutaminase (tTG), involved in PTM of gluten antigens in celiac disease, creates negatively charged peptides favored by T1D-predisposing HLA-DQ molecules, offering an attractive candidate modifying islet autoantigens in T1D. The highly predisposing HLA-DQ8cis/trans molecules share preferences for negatively charged peptides, as well as distinct peptide-binding… CONTINUE READING
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