Posttranslational modification of Galphao1 generates Galphao3, an abundant G protein in brain.

@article{Exner1999PosttranslationalMO,
  title={Posttranslational modification of Galphao1 generates Galphao3, an abundant G protein in brain.},
  author={T Exner and Ole N Jensen and Matthias Mann and Christiane Kleuss and B. Meinecke N{\"u}rnberg},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 4},
  pages={1327-32}
}
Galphao, the most abundant G protein in mammalian brain, occurs at least in two subforms, i.e., Galphao1 and Galphao2, derived by alternative splicing of the mRNA. A third Galphao1-related isoform, Galphao3, has been purified, representing about 30% of total Go in brain. Initial studies revealed distinct biochemical properties of Galphao3 as compared with other Galphao isoforms. In matrix-assisted laser desorption/ionization peptide mass mapping of gel-isolated Galphao1 and Galphao3, C-terminal… CONTINUE READING

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