Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43

@article{Skene1989PosttranslationalMA,
  title={Posttranslational membrane attachment and dynamic fatty acylation of a neuronal growth cone protein, GAP-43},
  author={J. H. Pate Skene and Istv{\'a}n Vir{\'a}g},
  journal={The Journal of Cell Biology},
  year={1989},
  volume={108},
  pages={613 - 624}
}
Growth cones, the motile apparatus at the ends of elongating axons, are sites of extensive and dynamic membrane-cytoskeletal interaction and insertion of new membrane into the growing axon. One of the most abundant proteins in growth cone membranes is a protein designated GAP-43, whose synthesis increases dramatically in most neurons during periods of axon development or regeneration. We have begun to explore the role of GAP-43 in growth cone membrane functions by asking how the protein… CONTINUE READING

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