Posttranslational control of cyclic AMP-dependent protein kinase by phorbol ester in normal but not in chemically transformed 3T3 cells.


Protein kinase C (PKC) and cyclic AMP-dependent protein kinase (PKA) are important for normal cell proliferation. We show that both kinases are down-regulated by a phorbol ester tumor promoter in nontumorigenic murine BALB/c 3T3 fibroblasts (A31 cells), whereas only PKC responded to the phorbol ester in a chemically transformed derivative cell line (DMBA31… (More)


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