Posttranslational Modifications of Proopiomelanocortin in Vertebrates and Their Biological Significance

@article{Takahashi2013PosttranslationalMO,
  title={Posttranslational Modifications of Proopiomelanocortin in Vertebrates and Their Biological Significance},
  author={Akiyoshi Takahashi and Kanta Mizusawa},
  journal={Frontiers in Endocrinology},
  year={2013},
  volume={4}
}
Proopiomelanocortin (POMC) is the precursor of several peptide hormones generated in the pituitary gland. After biosynthesis, POMC undergoes several posttranslational modifications, including proteolytic cleavage, acetylation, amidation, phosphorylation, glycosylation, and disulfide linkage formation, which generate mature POMC-derived peptides. Therefore, POMC is a useful model for the investigation of posttranslational modifications. These processes have been extensively investigated in… 

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