Posttranslational Modifications of Rad51 Protein and Its Direct Partners: Role and Effect on Homologous Recombination – Mediated DNA Repair

@inproceedings{Popova2011PosttranslationalMO,
  title={Posttranslational Modifications of Rad51 Protein and Its Direct Partners: Role and Effect on Homologous Recombination – Mediated DNA Repair},
  author={Milena Popova and Sébastien Henry and Fabrice Fleury},
  year={2011}
}
Double-strand breaks (DSB) are probably the most deleterious form of DNA alteration in a cell. They may arise from ionizing radiation, free radicals, chemicals, or during replication of single-strand breaks. There are two distinct and complementary mechanisms for DSB repair: non-homologous end-joining (NHEJ) and homologous recombination (HR). Both repair pathways are important for the elimination of DSBs in eukaryotes. Although the mechanisms of the cellular choice between these two pathways… CONTINUE READING

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