Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism

  title={Posttranslational Modification of 6-phosphofructo-1-kinase as an Important Feature of Cancer Metabolism},
  author={Andreja {\vS}merc and Eva Sodja and Matic Legi{\vs}a},
  booktitle={PloS one},
BACKGROUND Human cancers consume larger amounts of glucose compared to normal tissues with most being converted and excreted as lactate despite abundant oxygen availability (Warburg effect). The underlying higher rate of glycolysis is therefore at the root of tumor formation and growth. Normal control of glycolytic allosteric enzymes appears impaired in tumors; however, the phenomenon has not been fully resolved. METHODOLOGY/PRINCIPAL FINDINGS In the present paper, we show evidence that the… CONTINUE READING


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