Posttranscriptional repression of the cel gene of the ColE7 operon by the RNA-binding protein CsrA of Escherichia coli

@inproceedings{Yang2010PosttranscriptionalRO,
  title={Posttranscriptional repression of the cel gene of the ColE7 operon by the RNA-binding protein CsrA of Escherichia coli},
  author={Tsung-Yeh Yang and Yun-Min Sung and Guang-Sheng Lei and Tony Romeo and K. -F. Chak},
  booktitle={Nucleic acids research},
  year={2010}
}
Carbon storage regulator (CsrA) is a eubacterial RNA-binding protein that acts as a global regulator of many functionally diverse chromosomal genes. Here, we reveal that CsrA represses expression from an extrachromosomal element of Escherichia coli, the lysis gene (cel) of the ColE7 operon (cea-cei-cel). This operon and colicin expression are activated upon SOS response. Disruption of csrA caused approximately 5-fold increase of the lysis protein. Gel mobility shift assays established that both… CONTINUE READING

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