Posttranscriptional regulation of retroviral gene expression: primary RNA transcripts play three roles as pre‐mRNA, mRNA, and genomic RNA

@article{Leblanc2013PosttranscriptionalRO,
  title={Posttranscriptional regulation of retroviral gene expression: primary RNA transcripts play three roles as pre‐mRNA, mRNA, and genomic RNA},
  author={J. Leblanc and Jason E Weil and K. Beemon},
  journal={Wiley Interdisciplinary Reviews: RNA},
  year={2013},
  volume={4}
}
After reverse transcription of the retroviral RNA genome and integration of the DNA provirus into the host genome, host machinery is used for viral gene expression along with viral proteins and RNA regulatory elements. Here, we discuss co‐transcriptional and posttranscriptional regulation of retroviral gene expression, comparing simple and complex retroviruses. Cellular RNA polymerase II synthesizes full‐length viral primary RNA transcripts that are capped and polyadenylated. All retroviruses… Expand
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