Posttranscriptional regulation of macrophage tissue factor expression by antioxidants.

  title={Posttranscriptional regulation of macrophage tissue factor expression by antioxidants.},
  author={Guy F Brisseau and Alan P. B. Dackiw and Pak Yan Cheung and Natasha Christie and Ori D. Rotstein},
  volume={85 4},
Tissue factor (TF) expression by cells of monocyte/macrophage lineage represents an important mechanism underlying the initiation of fibrin deposition at sites of extravascular inflammation. Recent evidence suggests a role for oxidant stress in the signalling pathway of various cell types by virtue of its ability to induce DNA binding of various transcription factors, including nuclear factor kappa B and AP-1. The effect of antioxidant treatment on lipopolysaccharide (LPS)-induced TF expression… CONTINUE READING
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