Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.

@article{Ikeda2003PosttranscriptionalRO,
  title={Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.},
  author={Yuika Ikeda and Sumiko Abe-Dohmae and Youichi Munehira and Ryo Aoki and Shinobu Kawamoto and Akiko Furuya and Kenya Shitara and Teruo Amachi and Noriyuki Kioka and Michinori Matsuo and Shinji Yokoyama and Kazumitsu Ueda},
  journal={Biochemical and biophysical research communications},
  year={2003},
  volume={311 2},
  pages={
          313-8
        }
}
ABCA7 is expressed predominantly in myelo-lymphatic tissues or reticuloendothelial cells. Physiological role and function of this protein are not fully understood. We isolated the full-length cDNA (type I) and a splicing variant cDNA (type II) of human ABCA7, and developed monoclonal antibodies against extracellular domain (ECD)1 of ABCA7. RT-PCR experiments suggested that human ABCA7 gene produced the type II mRNA in a tissue-specific manner. Immunostaining revealed that the type I ABCA7… CONTINUE READING

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