Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.

  title={Posttranscriptional regulation of human ABCA7 and its function for the apoA-I-dependent lipid release.},
  author={Y. Ikeda and S. Abe-Dohmae and Youichi Munehira and R. Aoki and S. Kawamoto and A. Furuya and K. Shitara and T. Amachi and N. Kioka and M. Matsuo and S. Yokoyama and K. Ueda},
  journal={Biochemical and biophysical research communications},
  volume={311 2},
  • Y. Ikeda, S. Abe-Dohmae, +9 authors K. Ueda
  • Published 2003
  • Medicine, Biology
  • Biochemical and biophysical research communications
  • ABCA7 is expressed predominantly in myelo-lymphatic tissues or reticuloendothelial cells. Physiological role and function of this protein are not fully understood. We isolated the full-length cDNA (type I) and a splicing variant cDNA (type II) of human ABCA7, and developed monoclonal antibodies against extracellular domain (ECD)1 of ABCA7. RT-PCR experiments suggested that human ABCA7 gene produced the type II mRNA in a tissue-specific manner. Immunostaining revealed that the type I ABCA7… CONTINUE READING
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