Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells.

@article{Deguchi2013PosttranscriptionalRO,
  title={Posttranscriptional regulation of histone lysine methyltransferase GLP in embryonic male mouse germ cells.},
  author={Katsuaki Deguchi and Go Nagamatsu and Hitoshi Miyachi and Yuzuru Kato and Sumiyo Morita and Hiroshi Kimura and Satsuki Kitano and Izuho Hatada and Yumiko Saga and Makoto Tachibana and Yoichi Shinkai},
  journal={Biology of reproduction},
  year={2013},
  volume={88 2},
  pages={
          36
        }
}
The epigenetic status of germ cells changes dynamically during development. In this study, we analyzed the dynamics of histone H3 lysine 9 dimethylation (H3K9me2), a highly conserved mark of epigenetic silencing, and the expression of two lysine methyltransferases, G9a/Ehmt2/KMT1C and GLP/Ehmt1/KMT1D, in murine male embryonic germ cells after sex determination. Our previous studies established that G9a and GLP are the primary enzymes for H3K9me2 and predominantly exist as a G9a-GLP heteromeric… CONTINUE READING

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