Posttranscriptional regulation of alpha-catenin expression is required for Wnt signaling in L cells.

@article{Takahashi2000PosttranscriptionalRO,
  title={Posttranscriptional regulation of alpha-catenin expression is required for Wnt signaling in L cells.},
  author={Nobuki Takahashi and Seiichiro Ishihara and Shinji Takada and Shoichiro Tsukita and Akira Nagafuchi},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={277 3},
  pages={691-8}
}
alpha-Catenin is an essential component of the cadherin-catenin cell-cell adhesion complex. An excess amount of alpha-catenin also affects the Wnt signaling pathway probably through its direct binding to beta-catenin. Here, we examined the molecular mechanisms of the posttranscriptional regulation of alpha-catenin expression. We constructed an expression vector with alpha-catenin cDNA lacking the 5'-untranslated sequence. In L cell transfectants stably expressing mRNA derived from this vector… CONTINUE READING

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