Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors.

@article{Piechaczyk1985PosttranscriptionalMA,
  title={Posttranscriptional mechanisms are responsible for accumulation of truncated c-myc RNAs in murine plasma cell tumors.},
  author={Marc Piechaczyk and Jing Qing Yang and Jean Marie Blanchard and Philippe Jeanteur and Kenneth B. Marcu},
  journal={Cell},
  year={1985},
  volume={42 2},
  pages={589-97}
}
c-myc Messenger RNAs are known to be extremely unstable (t1/2 = 10 min) in normal and tumor cells, suggesting that degradation could play an important role in regulating their steady state level in the cytoplasm. We have investigated the stabilities of c-myc mRNAs in three murine plasmacytomas, where the c-myc gene either remains intact (ABPC20) or exists in a truncated form (MPC-11 and J558L) subsequent to 6;15 or 12;15 chromosome translocations respectively, and in an A-MuLV-induced pre-B… CONTINUE READING

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