Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland.

@article{Helm2014PosttranscriptionalRM,
  title={Posttranscriptional RNA Modifications: playing metabolic games in a cell's chemical Legoland.},
  author={Mark Helm and Juan D. Alfonzo},
  journal={Chemistry & biology},
  year={2014},
  volume={21 2},
  pages={174-85}
}
Nature combines existing biochemical building blocks, at times with subtlety of purpose. RNA modifications are a prime example of this, where standard RNA nucleosides are decorated with chemical groups and building blocks that we recall from our basic biochemistry lectures. The result: a wealth of chemical diversity whose full biological relevance has remained elusive despite being public knowledge for some time. Here, we highlight several modifications that, because of their chemical intricacy… CONTINUE READING
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