Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.

@article{Pekalski2013PostthymicEI,
  title={Postthymic expansion in human CD4 naive T cells defined by expression of functional high-affinity IL-2 receptors.},
  author={Marcin L. Pekalski and Ricardo C Ferreira and Richard M.R. Coulson and Antony J Cutler and Hui Guo and Deborah J. Smyth and Kate Downes and Calliope A. Dendrou and Xaquin Castro Dopico and Laura Esposito and Gillian Coleman and Helen E. Stevens and Sarah L Nutland and Neil M. Walker and Catherine Guy and David B Dunger and Chris Wallace and Timothy I M Tree and John A. Todd and Linda S. Wicker},
  journal={Journal of immunology},
  year={2013},
  volume={190 6},
  pages={
          2554-66
        }
}
As the thymus involutes with age, the maintenance of peripheral naive T cells in humans becomes strongly dependent on peripheral cell division. However, mechanisms that orchestrate homeostatic division remain unclear. In this study we present evidence that the frequency of naive CD4 T cells that express CD25 (IL-2 receptor α-chain) increases with age on subsets of both CD31(+) and CD31(-) naive CD4 T cells. Analyses of TCR excision circles from sorted subsets indicate that CD25(+) naive CD4 T… CONTINUE READING
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