Postsynthetic conjugation of RNA to carboxylate and dicarboxylate molecules.

@article{Shemesh2015PostsyntheticCO,
  title={Postsynthetic conjugation of RNA to carboxylate and dicarboxylate molecules.},
  author={Yossi Shemesh and Eylon Yavin},
  journal={Nucleosides, nucleotides & nucleic acids},
  year={2015},
  volume={34 11},
  pages={753-62}
}
Carboxylates and dicarboxylates are important phosphate mimics. Herein, we present a simple synthetic route for the preparation of RNA carboxylate/dicarboxylate conjugates, starting from suitably protected NH2- and COOH-containing molecules that are coupled to the RNA on the solid support. The key point in our method was the use of trimethylsilylethanol… CONTINUE READING