Postsynaptic short-chain neurotoxins from Pseudonaja textilis. cDNA cloning, expression and protein characterization.

@article{Gong1999PostsynapticSN,
  title={Postsynaptic short-chain neurotoxins from Pseudonaja textilis. cDNA cloning, expression and protein characterization.},
  author={Nanling Gong and Arunmozhiarasi Armugam and Kandiah Jeyaseelan},
  journal={European journal of biochemistry},
  year={1999},
  volume={265 3},
  pages={982-9}
}
Two lethal proteins, which specifically bind to the nAChR from Torpedo californica, were isolated from the venom of Pseudonaja textilis, the common brown snake from Australia. The isolated proteins have masses of 6236 and 6345 Da and are structurally related to short-chain neurotoxins from other elapids. Six cDNAs encoding isoforms of related neurotoxins were cloned using the RT-PCR of the venom gland mRNAs. The sequences of the corresponding proteins consist of 57-58 amino acid residues and… CONTINUE READING

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