Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains

  title={Postsynaptic regulation of synaptic plasticity by synaptotagmin 4 requires both C2 domains},
  author={Cynthia F. Barber and Ramon A Jorquera and Jan Elizabeth Melom and J. Troy Littleton},
  booktitle={The Journal of cell biology},
Ca(2+) influx into synaptic compartments during activity is a key mediator of neuronal plasticity. Although the role of presynaptic Ca(2+) in triggering vesicle fusion though the Ca(2+) sensor synaptotagmin 1 (Syt 1) is established, molecular mechanisms that underlie responses to postsynaptic Ca(2+) influx remain unclear. In this study, we demonstrate that fusion-competent Syt 4 vesicles localize postsynaptically at both neuromuscular junctions (NMJs) and central nervous system synapses in… CONTINUE READING


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