Postsynaptic membrane fusion and long-term potentiation.

@article{Lledo1998PostsynapticMF,
  title={Postsynaptic membrane fusion and long-term potentiation.},
  author={Pierre Marie Lledo and Xiao-Hui Zhang and Thomas C S{\"u}dhof and Robert C Malenka and Roger A Nicoll},
  journal={Science},
  year={1998},
  volume={279 5349},
  pages={399-403}
}
The possibility that membrane fusion events in the postsynaptic cell may be required for the change in synaptic strength resulting from long-term potentiation (LTP) was examined. Introducing substances into the postsynaptic cell that block membrane fusion at a number of different steps reduced LTP. Introducing SNAP, a protein that promotes membrane fusion, into cells enhanced synaptic transmission, and this enhancement was significantly less when generated in synapses that expressed LTP. Thus… CONTINUE READING
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