Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaMKII and PKC activity

@article{Wang1995PostsynapticIO,
  title={Postsynaptic injection of Ca2+/CaM induces synaptic potentiation requiring CaMKII and PKC activity},
  author={Jin-Hui Wang and Paul A. T. Kelly},
  journal={Neuron},
  year={1995},
  volume={15},
  pages={443-452}
}
CA2+-regulated protein kinases play critical roles in long-term potentiation (LTP). To understand the role of Ca2+/calmodulin (CaM) signaling pathways in synaptic transmission better, Ca2+/CaM was injected into hippocampal CA1 neurons. Ca2+/CaM induced significant potentiation of excitatory synaptic responses, which was blocked by coinjection of a CaM-binding peptide and was not induced by injections of Ca2+ or CaM alone. Reciprocal experiments demonstrated that Ca2+/CaM-induced synaptic… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 73 references

Calmodulin, cell growth and gene expression

Trends in Neurosciences • 1989
View 10 Excerpts
Highly Influenced

Mechanism of protein kinase C activation during the induction and maintenance of long-term potentiation probed using a selective peptide substrate.

Proceedings of the National Academy of Sciences of the United States of America • 1993
View 4 Excerpts
Highly Influenced

Persistent activation of the zeta isoform of protein kinase C in the maintenance of long-term potentiation.

Proceedings of the National Academy of Sciences of the United States of America • 1993
View 4 Excerpts
Highly Influenced

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