Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance

@article{Kaila1987PostsynapticFI,
  title={Postsynaptic fall in intracellular pH induced by GABA-activated bicarbonate conductance},
  author={K. Kaila and J. Voipio},
  journal={Nature},
  year={1987},
  volume={330},
  pages={163-165}
}
  • K. Kaila, J. Voipio
  • Published 1987
  • Biology, Medicine
  • Nature
  • Synaptic inhibition mediated by γ-aminobutyric acid (GABA) is known to involve opening of receptor-gated chloride channels1–3. Recent evidence indicates that these channels also show a significant permeability to the physiologically important bicarbonate anion4. In all the excitable cells studied to date, the intracellular pH (pHi) is higher than would be predicted from a passive distribution of H+ ions5–9, and consequently there is an outwardly directed electrochemical driving force for HCO3… CONTINUE READING
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