Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development

@article{Komai2006PostsynapticEI,
  title={Postsynaptic excitability is necessary for strengthening of cortical sensory responses during experience-dependent development},
  author={Shoji Komai and Pawel Licznerski and Ali Cetin and Jack Waters and Winfried Denk and Michael Brecht and Pavel Osten},
  journal={Nature Neuroscience},
  year={2006},
  volume={9},
  pages={1125-1133}
}
Sensory experience is necessary for normal cortical development. This has been shown by sensory deprivation and pharmacological perturbation of the cortex. Because these manipulations affect the cortical network as a whole, the role of postsynaptic cellular properties during experience-dependent development is unclear. Here we addressed the developmental role of somatodendritic excitability, which enables postsynaptic spike timing–dependent forms of plasticity, in rat somatosensory cortex. We… CONTINUE READING
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