Postsynaptic endocannabinoid release is critical to long-term depression in the striatum

  title={Postsynaptic endocannabinoid release is critical to long-term depression in the striatum},
  author={Gregory L. Gerdeman and Jennifer A. Ronesi and David M. Lovinger},
  journal={Nature Neuroscience},
The striatum functions critically in movement control and habit formation. The development and function of cortical input to the striatum are thought to be regulated by activity-dependent plasticity of corticostriatal glutamatergic synapses. Here we show that the induction of a form of striatal synaptic plasticity, long-term depression (LTD), is dependent on activation of the CB1 cannabinoid receptor. LTD was facilitated by blocking cellular endocannabinoid uptake, and postsynaptic loading of… 
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Decreased probability of neurotransmitter release underlies striatal long-term depression and postnatal development of corticostriatal synapses.
  • S. Choi, D. Lovinger
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1997
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Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses.
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Regional and postnatal heterogeneity of activity-dependent long-term changes in synaptic efficacy in the dorsal striatum.
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Dopamine-dependent synaptic plasticity in striatum during in vivo development.
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Selective involvement of mGlu1 receptors in corticostriatal LTD
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