Postsynaptic endocannabinoid release is critical to long-term depression in the striatum

@article{Gerdeman2002PostsynapticER,
  title={Postsynaptic endocannabinoid release is critical to long-term depression in the striatum},
  author={G. Gerdeman and J. Ronesi and D. Lovinger},
  journal={Nature Neuroscience},
  year={2002},
  volume={5},
  pages={446-451}
}
  • G. Gerdeman, J. Ronesi, D. Lovinger
  • Published 2002
  • Medicine, Biology
  • Nature Neuroscience
  • The striatum functions critically in movement control and habit formation. The development and function of cortical input to the striatum are thought to be regulated by activity-dependent plasticity of corticostriatal glutamatergic synapses. Here we show that the induction of a form of striatal synaptic plasticity, long-term depression (LTD), is dependent on activation of the CB1 cannabinoid receptor. LTD was facilitated by blocking cellular endocannabinoid uptake, and postsynaptic loading of… CONTINUE READING

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