Postsynaptic depolarization scales quantal amplitude in cortical pyramidal neurons.

@article{Leslie2001PostsynapticDS,
  title={Postsynaptic depolarization scales quantal amplitude in cortical pyramidal neurons.},
  author={Kenneth R. Leslie and Sacha B. Nelson and Gina G. Turrigiano},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2001},
  volume={21 19},
  pages={RC170}
}
Pyramidal neurons scale the strength of all of their excitatory synapses up or down in response to long-term changes in activity, and in the direction needed to stabilize firing rates. This form of homeostatic plasticity is likely to play an important role in stabilizing firing rates during learning and developmental plasticity, but the signals that translate a change in activity into global changes in synaptic strength are poorly understood. Some but not all of the effects of long-lasting… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 31 references

TrkB receptor ligands promote activity-dependent inhibitory synaptogenesis.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2000
View 4 Excerpts
Highly Influenced

Activity differentially regulates the surface expression of synaptic AMPA and NMDA glutamate receptors.

Proceedings of the National Academy of Sciences of the United States of America • 1998
View 7 Excerpts
Highly Influenced

Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1998
View 4 Excerpts
Highly Influenced

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

Proceedings of the National Academy of Sciences of the United States of America • 1992
View 6 Excerpts
Highly Influenced

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