Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats.

@article{Kim2002PostsynapticAM,
  title={Postsynaptic action mechanism of somatostatin on the membrane excitability in spinal substantia gelatinosa neurons of juvenile rats.},
  author={Sung-Hwan Kim and Woo Hyun Chung and Hyewhon Rhim and S-Y Eun and Sung Jun Jung and J Kim},
  journal={Neuroscience},
  year={2002},
  volume={114 4},
  pages={1139-48}
}
We used tight-seal, whole-cell recording in juvenile rat spinal slices to investigate the action of somatostatin on substantia gelatinosa neurons. Bath application of somatostatin caused a robust and repeatable hyperpolarization or outward current in substantia gelatinosa neurons. Somatostatin inhibited spontaneous action potentials in subpopulation of substantia gelatinosa neurons. The amplitude of dorsal root-evoked excitatory postsynaptic currents and the frequency of spontaneous excitatory… CONTINUE READING