Postsynaptic Target Specificity of Neurotrophin-Induced Presynaptic Potentiation

  title={Postsynaptic Target Specificity of Neurotrophin-Induced Presynaptic Potentiation},
  author={Alejandro F Schinder and Benedikt Berninger and Mu-Ming Poo},
The role of the target cell in neurotrophin-induced modifications of glutamatergic synaptic transmission was examined in cultured hippocampal neurons. Brain-derived neurotrophic factor (BDNF) induced rapid and persistent potentiation of evoked glutamate release when the postsynaptic neuron was glutamatergic, or excitatory (E-->E), but not when it was GABAergic, or inhibitory (E-->1). This target-specific action of BDNF was also found at divergent outputs of a single presynaptic neuron… CONTINUE READING