Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP

@inproceedings{Wu2017PostsynapticSM,
  title={Postsynaptic Synaptotagmins Mediate AMPA Receptor Exocytosis During LTP},
  author={Dick Wu and Taulant Bacaj and Wade Katsuji Morishita and Debanjan Goswami and Kristin L. Arendt and Wei Xu and Lu Chen and Robert C Malenka and Thomas C S{\"u}dhof},
  booktitle={Nature},
  year={2017}
}
Strengthening of synaptic connections by NMDA (N-methyl-d-aspartate) receptor-dependent long-term potentiation (LTP) shapes neural circuits and mediates learning and memory. During the induction of NMDA-receptor-dependent LTP, Ca2+ influx stimulates recruitment of synaptic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors, thereby strengthening synapses. How Ca2+ induces the recruitment of AMPA receptors remains unclear. Here we show that, in the pyramidal neurons of the… CONTINUE READING

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