Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP

  title={Postsynaptic Complexin Controls AMPA Receptor Exocytosis during LTP},
  author={Mohiuddin Ahmad and Jai Santosh Polepalli and Debanjan Goswami and Xiaofei Yang and Yea Jin Kaeser-Woo and Thomas C S{\"u}dhof and Robert C Malenka},
Long-term potentiation (LTP) is a compelling synaptic correlate of learning and memory. LTP induction requires NMDA receptor (NMDAR) activation, which triggers SNARE-dependent exocytosis of AMPA receptors (AMPARs). However, the molecular mechanisms mediating AMPAR exocytosis induced by NMDAR activation remain largely unknown. Here, we show that complexin, a protein that regulates neurotransmitter release via binding to SNARE complexes, is essential for AMPAR exocytosis during LTP but not for… CONTINUE READING