Poststatin, a new inhibitor of prolyl endopeptidase. IV. The chemical synthesis of poststain.

Abstract

Total synthesis of poststatin was achieved by both liquid phase and solid phase methods. In both methods, the (2R,3S)-3-amino-2-hydroxyvaleric acid moiety was incorporated into protected pentapeptides, and was oxidized to (S)-3-amino-2-oxovaleric acid (postine). Deprotection of the oxidized pentapeptides gave a specimen identical with natural poststatin in… (More)

Topics

Figures and Tables

Sorry, we couldn't extract any figures or tables for this paper.