Postreplication repair and PCNA modification in Schizosaccharomyces pombe.

  title={Postreplication repair and PCNA modification in Schizosaccharomyces pombe.},
  author={Jonathan Frampton and Anja Irmisch and Catherine Green and Andrea Neiss and Michelle Trickey and Helle D Ulrich and Kanji Furuya and Felicity Z. Watts and Antony M Carr and A. R. Lehmann},
  journal={Molecular biology of the cell},
  volume={17 7},
Ubiquitination of proliferating cell nuclear antigen (PCNA) plays a crucial role in regulating replication past DNA damage in eukaryotes, but the detailed mechanisms appear to vary in different organisms. We have examined the modification of PCNA in Schizosaccharomyces pombe. We find that, in response to UV irradiation, PCNA is mono- and poly-ubiquitinated in a manner similar to that in Saccharomyces cerevisiae. However in undamaged Schizosaccharomyces pombe cells, PCNA is ubiquitinated in S… CONTINUE READING