Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes.

@article{Kininis2009PostrecruitmentRO,
  title={Postrecruitment regulation of RNA polymerase II directs rapid signaling responses at the promoters of estrogen target genes.},
  author={Miltiadis Kininis and Gary D. Isaacs and Leighton J. Core and Nasun Hah and W Lee Kraus},
  journal={Molecular and cellular biology},
  year={2009},
  volume={29 5},
  pages={1123-33}
}
Under classical models for signal-dependent transcription in eukaryotes, DNA-binding activator proteins regulate the recruitment of RNA polymerase II (Pol II) to a set of target promoters. However, recent studies, as well as our results herein, show that Pol II is widely distributed (i.e., "preloaded") at the promoters of many genes prior to specific signaling events. How Pol II recruitment and Pol II preloading fit within a unified model of gene regulation is unclear. In addition, the… CONTINUE READING

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