Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.

Abstract

In the osteocalcin (OC) gene promoter, both independent positive and negative regulatory elements, as well as others with contiguous [TATA/glucocorticoid-responsive elements (GRE)] or overlapping [TATA/GRE, vitamin D-responsive enhancer elements (VDRE)/AP-1, and OC box/AP-1] domains, are sites for modifications in protein-DNA interactions. In the present… (More)

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Cite this paper

@article{Owen1993PostproliferativeTO, title={Postproliferative transcription of the rat osteocalcin gene is reflected by vitamin D-responsive developmental modifications in protein-DNA interactions at basal and enhancer promoter elements.}, author={Thomas A. Owen and Rita Bortell and Victoria Shalhoub and Anika Heinrichs and Janet L. Stein and Guenter Stein and Jane B. Lian}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1993}, volume={90 4}, pages={1503-7} }