Postprandial total ghrelin suppression is modulated by melanocortin signaling in humans.


CONTENTS Ghrelin is implicated in meal initiation because circulating levels increase before and fall after meal consumption. In rodents, ghrelin stimulates food intake via hypothalamic circuits expressing the melanocortin 4 receptor (MC4R). OBJECTIVE The aim of the study was to investigate the impact of central melanocortinergic tone on ghrelin secretion… (More)
DOI: 10.1210/jc.2012-2553


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