Postprandial lipemia induces pancreatic α cell dysfunction characteristic of type 2 diabetes: studies in healthy subjects, mouse pancreatic islets, and cultured pancreatic α cells.

@article{Niederwanger2014PostprandialLI,
  title={Postprandial lipemia induces pancreatic α cell dysfunction characteristic of type 2 diabetes: studies in healthy subjects, mouse pancreatic islets, and cultured pancreatic α cells.},
  author={Andreas Niederwanger and Christian Ciardi and Tobias Tatarczyk and Mohammad Imran Khan and Martin Hermann and Christof Mittermair and Ramona Al-Zoairy and Karin Salzmann and Michael T. Pedrini},
  journal={The American journal of clinical nutrition},
  year={2014},
  volume={100 5},
  pages={1222-31}
}
BACKGROUND Type 2 diabetes is associated with pancreatic α cell dysfunction, characterized by elevated fasting plasma glucagon concentrations and inadequate postprandial glucose- and insulin-induced suppression of glucagon secretion. The cause and the underlying mechanisms of α cell dysfunction are unknown. OBJECTIVE Because Western dietary habits cause postprandial lipemia for a major part of a day and, moreover, increase the risk of developing type 2 diabetes, we tested the hypothesis that… CONTINUE READING
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