Postprandial increase of complement component 3 in normolipidemic patients with coronary artery disease: effects of expanded-dose simvastatin.

@article{Halkes2001PostprandialIO,
  title={Postprandial increase of complement component 3 in normolipidemic patients with coronary artery disease: effects of expanded-dose simvastatin.},
  author={Constantijn J. M. Halkes and Harriet van Dijk and Peter P. T. de Jaegere and Herbert W.M. Plokker and Yvonne J M van der Helm and D. Willem Erkelens and Manuel Castro Cabezas},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2001},
  volume={21 9},
  pages={
          1526-30
        }
}
Plasma concentrations of the third complement component (C3) predict the risk of myocardial infarction. Because chylomicrons stimulate C3 production by adipocytes in vitro, we investigated plasma C3 changes in vivo after an oral fat load. Thirty-seven subjects (20 normolipidemic patients with coronary artery disease [CAD] and 17 healthy control subjects) underwent an oral fat load (50 g/m(2)). C3 was measured at baseline and at 2-hour intervals after fat intake for 10 hours. The effects of… CONTINUE READING
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