Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues.

@article{Firth1986PostprandialHI,
  title={Postprandial hyperglycemia in patients with noninsulin-dependent diabetes mellitus. Role of hepatic and extrahepatic tissues.},
  author={Robert Firth and Patrick M. Bell and Harold Michael Marsh and I F Hansen and Robert A. Rizza},
  journal={The Journal of clinical investigation},
  year={1986},
  volume={77 5},
  pages={1525-32}
}
Patients with noninsulin-dependent diabetes mellitus (NIDDM) have both preprandial and postprandial hyperglycemia. To determine the mechanism responsible for the postprandial hyperglycemia, insulin secretion, insulin action, and the pattern of carbohydrate metabolism after glucose ingestion were assessed in patients with NIDDM and in matched nondiabetic subjects using the dual isotope and forearm catheterization techniques. Prior to meal ingestion, hepatic glucose release was increased (P less… CONTINUE READING

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