Postpartum estrogen withdrawal impairs GABAergic inhibition and LTD induction in basolateral amygdala complex via down-regulation of GPR30.

@article{Yang2017PostpartumEW,
  title={Postpartum estrogen withdrawal impairs GABAergic inhibition and LTD induction in basolateral amygdala complex via down-regulation of GPR30.},
  author={Rong Yang and Baofeng Zhang and Ting-Ting Chen and Su-yun Zhang and Ling Chen},
  journal={European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology},
  year={2017},
  volume={27 8},
  pages={759-772}
}
Postpartum estrogen (E2) withdrawal is known to be a particularly vulnerable time for depressive symptoms. In this study, ovariectomized (OVX) mice were treated with co-administration of estradiol benzoate and progesterone (E2/P4) followed by administration of E2 alone (E2) and a subsequent E2 withdrawal (EW) to mimic the hormonal changes during pregnancy… CONTINUE READING