Postorgasmic Illness Syndrome: Two Cases

  title={Postorgasmic Illness Syndrome: Two Cases},
  author={Marcel D. Waldinger and Dave Henri Schweitzer},
  journal={Journal of Sex \& Marital Therapy},
  pages={251 - 255}
We describe the symptoms of a postejaculatory syndrome in two men with spontaneous ejaculations. The syndrome consists of severe fatigue, intense warmth, and a flulike state, with generalized myalgia. These symptoms occur rapidly after ejaculation and only disappear after 4 to 7 days. The symptoms are so severe that sexual activity is avoided. The cluster of symptoms is named postorgasmic illness syndrome (POIS). To date, no explanation has been offered for the etiology and pathogenesis of the… 
The clinical assessment and differentiation of the diagnosis was difficult and consisted in several clinical criteria, a functional test and allergy valuation, and the combination of symptoms and pathophysiological mechanisms pointed to other sex related allergies, such as seminal plasma protein allergy.
Post-orgasmic illness syndrome: a case report
A case of POIS with a manifestation of atopy that may be consistent with the allergy hypothesis is presented and it is shown that this syndrome may have a psychosomatic etiology.
Post-orgasmic Illness Syndrome
The common symptoms of Post-orgasmic illness syndrome include cognitive disturbance, fatigue, memory and concentration issues, and sometimes flulike symptoms such as rhinitis, nasal congestion, and myalgia.
Post-Orgasmic Illness Syndrome: A Review.
Clinical experience with post-orgasmic illness syndrome (POIS) patients—characteristics and possible treatment modality
  • Y. Reisman
  • Medicine, Psychology
    International Journal of Impotence Research
  • 2020
A series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners are described, to increase knowledge about this syndrome and possible treatment modality.
The first Tunisian case of postorgasmic illness syndrome: A case report
Through a clinical observation, the first case diagnosed in Tunisia is illustrated and the difficulties in the etiological diagnosis and the therapeutic management of this syndrome are illustrated.
Post-orgasmic Illness Syndrome: A Closer Look
This syndrome still needs more research to understand its mechanisms to obtain clearer treatment, and the clinician's awareness is needed to recognize this syndrome so that it is not misdiagnosed.
Post orgasmic illness syndrome (POIS)
  • M. Waldinger
  • Biology, Medicine
    Translational andrology and urology
  • 2016
Post orgasmic illness syndrome is a chronic disorder that manifests itself in POIS “attacks” that occur within a few minutes to a few hours after ejaculation, and disappear spontaneously after 3 to 7 days.


Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study.
Patients treated with paroxetine had significantly greater clinical improvement than the patients given placebo.
An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation.
The results suggest that premature ejaculation could be operationally defined as an IELT < 1 min in more than 90% of episodes of sexual intercourse, independent of age and duration of relationship.
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Clinical Toxicity of Cytokines Used As Haemopoietic Growth Factors
Safety of long term administration of these cytokines has not yet been determined, and IL-3-induced disease progression in myelodysplastic patients has been suggested, but the possible occurrence of several adverse events, i.e. bone disorders, leukaemia, unmasking or acceleration of underlying disease, require further investigation in patients receiving prolonged treatment.
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Positive correlations between measures are consistent with a possible functional role for OT in human sexual response and subjective orgasm intensity correlated significantly with increased levels of OT in multiorgasmic women only.
Neuroendocrine response to film-induced sexual arousal in men and women
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Neuroendocrine response to filminduced sexual arousal in men and women
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