Postorgasmic Illness Syndrome: Two Cases

  title={Postorgasmic Illness Syndrome: Two Cases},
  author={Marcel D. Waldinger and Dave Henri Schweitzer},
  journal={Journal of Sex \& Marital Therapy},
  pages={251 - 255}
We describe the symptoms of a postejaculatory syndrome in two men with spontaneous ejaculations. The syndrome consists of severe fatigue, intense warmth, and a flulike state, with generalized myalgia. These symptoms occur rapidly after ejaculation and only disappear after 4 to 7 days. The symptoms are so severe that sexual activity is avoided. The cluster of symptoms is named postorgasmic illness syndrome (POIS). To date, no explanation has been offered for the etiology and pathogenesis of the… 


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Preejaculatory illness syndrome: Two cases of a rare psychosomatic disorder

Two cases of preejaculatory illness syndrome are presented, which shared common symptoms of sympathetic over activity, the sensation of impending death, and muscle atonia with subsequent failure to ejaculate.

Post-orgasmic Illness Syndrome

The common symptoms of Post-orgasmic illness syndrome include cognitive disturbance, fatigue, memory and concentration issues, and sometimes flulike symptoms such as rhinitis, nasal congestion, and myalgia.

Post-Orgasmic Illness Syndrome: A Review.

Clinical experience with post-orgasmic illness syndrome (POIS) patients—characteristics and possible treatment modality

  • Y. Reisman
  • Medicine, Psychology
    International Journal of Impotence Research
  • 2020
A series of 14 highly selected patients who were actively looking for medical help as POIS has a significant effect on patients and their partners are described, to increase knowledge about this syndrome and possible treatment modality.

The first Tunisian case of postorgasmic illness syndrome: A case report

Through a clinical observation, the first case diagnosed in Tunisia is illustrated and the difficulties in the etiological diagnosis and the therapeutic management of this syndrome are illustrated.

Post-orgasmic Illness Syndrome: A Closer Look

This syndrome still needs more research to understand its mechanisms to obtain clearer treatment, and the clinician's awareness is needed to recognize this syndrome so that it is not misdiagnosed.



Paroxetine treatment of premature ejaculation: a double-blind, randomized, placebo-controlled study.

Patients treated with paroxetine had significantly greater clinical improvement than the patients given placebo.

An empirical operationalization study of DSM-IV diagnostic criteria for premature ejaculation.

The results suggest that premature ejaculation could be operationally defined as an IELT < 1 min in more than 90% of episodes of sexual intercourse, independent of age and duration of relationship.

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Relationships among cardiovascular, muscular, and oxytocin responses during human sexual activity

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Inhibitory influence of oxytocin infusion on contingent negative variation and some memory tasks in normal men

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Neuroendocrine response to filminduced sexual arousal in men and women

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