Postoperative venous thromboembolism and brain tumors: part III. Biochemical profile


The plasminogen activator activity of 31 human brain tumor samples was assessed and the results correlated with clinical parameters and the postoperative occurrence of venous thrombosis. A significant negative correlation was found between plasminogen activator activity and venous thrombosis (P = 0.02), while positive correlations were observed between plasminogen activator activity and peritumoral brain edema (P = 0.03) and alpha2 antiplasmin measured in the systemic circulation (P = 0.01). Tissue plasminogen activator was found in higher concentrations in meningioma tissue but did not correlate significantly with the occurrence of venous thrombosis. The results of this study suggest a local enzymatic degradation effect of plasminogen activator on thrombogenic substances present in the brain tumor and/or its environment.

DOI: 10.1007/BF00177614

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@article{Sawaya1992PostoperativeVT, title={Postoperative venous thromboembolism and brain tumors: part III. Biochemical profile}, author={Raymond E. Sawaya and Robert F. Highsmith}, journal={Journal of Neuro-Oncology}, year={1992}, volume={14}, pages={113-118} }