Postoperative seizures: epidemiology, pathology, and prophylaxis.

  title={Postoperative seizures: epidemiology, pathology, and prophylaxis.},
  author={Shinya Manaka and Buichi Ishijima and Yoshiaki Mayanagi},
  journal={Neurologia medico-chirurgica},
  volume={43 12},
  pages={589-600; discussion 600}
The risk of epileptic seizures after craniotomy is extremely important but the incidence of postoperative epilepsy varies greatly, depending on the patient's conditions such as primary diseases, severity of surgical insult, and pre-existing epilepsy. Animal studies suggest that neurosurgical insults lead to seizures by two different mechanisms: One mechanism is mediated by free radical generation and the other by impaired ion balance across the cell membrane caused by ischemia or hypoxia… CONTINUE READING


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