Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes.

@article{Spittler2001PostoperativeGI,
  title={Postoperative glycyl-glutamine infusion reduces immunosuppression: partial prevention of the surgery induced decrease in HLA-DR expression on monocytes.},
  author={Andreas Spittler and Thomas Sautner and Alexander Gornikiewicz and Nicole Manhart and Rudolf Oehler and Martin W Bergmann and Reinhold Fuegger and Erich Roth},
  journal={Clinical nutrition},
  year={2001},
  volume={20 1},
  pages={37-42}
}
BACKGROUND AND AIMS Surgery, trauma and inflammation reduce HLA-DR expression on monocytes, which is associated with an increased susceptibility to infection and sepsis. Furthermore, surgery decreases plasma glutamine (GLN) levels. The expression of HLA-DR on human monocytes in vitro is dependent on the concentration of GLN in the culture medium. We therefore hypothesized that postoperative infusions of glutamine-dipeptides would prevent the decreased HLA-DR expression on monocytes. METHODS… CONTINUE READING

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