Postoperative demand for analgesics in relation to individual levels of endorphins and substance P in cerebrospinal fluid

@article{Tamsen1982PostoperativeDF,
  title={Postoperative demand for analgesics in relation to individual levels of endorphins and substance P in cerebrospinal fluid},
  author={Anders Tamsen and Tsukasa Sakurada and Agneta Wahlstr{\"o}m and Lars Terenius and Per Hartvig},
  journal={PAIN},
  year={1982},
  volume={13},
  pages={171-183}
}
  • Anders Tamsen, Tsukasa Sakurada, +2 authors Per Hartvig
  • Published in PAIN 1982
  • Medicine
  • Fourteen adult patients were allowed to self-administer small intravenous doses of pethidine to relieve postoperative pain. Thirteen of the patients obtained subjectively satisfactory analgesia while establishing steady-state levels of pethidine in plasma. The individual demand for pethidine was related to individual levels of fraction I endorphins and substance P-like immunoreactivity in the cerebrospinal fluid (CSF). There was a significant and inverse relationship between preoperative… CONTINUE READING

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