Postoperative delirium: the tryptophan dyregulation model.

  title={Postoperative delirium: the tryptophan dyregulation model.},
  author={Michael C Lewis and Sheila Ryan Barnett},
  journal={Medical hypotheses},
  volume={63 3},
A model previously presented by Uchida in this journal [Med. Hypotheses 53 (1997) 103] described a mechanism for postoperative delirium. It described an increased level of melatonin resulting in a central "serotonin shortage". This construct adequately explained only the hypoactive type of delirium. Recently it has been shown that a reduction in urinary metabolites of melatonin is associated with hyperactive delirium, whereas urinary metabolites were increased in the hypoactive variant. These… CONTINUE READING


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