Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.

@article{Mooney2007PostoperativeAA,
  title={Postoperative anti-Tgf-beta2 antibody therapy improves intracranial volume and craniofacial growth in craniosynostotic rabbits.},
  author={Mark P. Mooney and H. Wolfgang Losken and Amr Moursi and Jocelyn M. Shand and Gregory M. Cooper and Chris Curry and Lillian Ho and Anne M. Burrows and Eric J. Stelnicki and Joseph E. Losee and Lynne A. Opperman and Michael I. Siegel},
  journal={The Journal of craniofacial surgery},
  year={2007},
  volume={18 2},
  pages={
          336-46; discussion 347-9
        }
}
  • Mark P. Mooney, H. Wolfgang Losken, +9 authors Michael I. Siegel
  • Published in
    The Journal of craniofacial…
    2007
  • Medicine
  • Postoperative resynostosis and secondary craniofacial growth abnormalities are common sequelae after craniofacial surgery. It has been suggested that an overexpression of transforming growth factor-beta2 (Tgf-beta2) may be related to craniosynostosis and contribute to postoperative resynostosis. Interference with Tgf-beta2 function using neutralizing antibodies may inhibit resynostosis and improve postoperative craniofacial growth; the present study was designed to test this hypothesis. Twenty… CONTINUE READING

    Create an AI-powered research feed to stay up to date with new papers like this posted to ArXiv

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 20 CITATIONS

    Comparison of Craniofacial Phenotype in Craniosynostotic Rabbits Treated with Anti–Tgf-β2 at Suturectomy Site

    VIEW 8 EXCERPTS
    CITES BACKGROUND & RESULTS

    Rescue of Premature Coronal Suture Fusion with TGF-β2 Neutralizing Antibody in Rabbits with Delayed-Onset Synostosis

    VIEW 5 EXCERPTS
    CITES METHODS & BACKGROUND

    Molecular Analysis of Ephrin A4 and Ephrin B1 in a Rabbit Model of Craniosynostosis

    VIEW 1 EXCERPT
    CITES BACKGROUND

    Molecular Analysis of Gli3, Ihh, Rab23, and Jag1 in a Rabbit Model of Craniosynostosis

    VIEW 2 EXCERPTS
    CITES BACKGROUND & METHODS

    Genetic Homozygosity and Phenotypic Variability in Craniosynostotic Rabbits

    VIEW 2 EXCERPTS
    CITES METHODS

    Transforming Growth Factor-β3 Therapy Delays Postoperative Reossification and Improves Craniofacial Growth in Craniosynostotic Rabbits

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 89 REFERENCES

    Cytokine therapy for craniosynostosis.

    VIEW 9 EXCERPTS

    Delivery of transforming growth factor-beta2-perturbing antibody in a collagen vehicle inhibits cranial suture fusion in calvarial organ culture.

    VIEW 4 EXCERPTS

    Fibroblasts growth factor receptor mutations

    • Cohen MM
    • Mutaz B. Habal, MD
    • 2007

    Surgical treatment of craniosynostosis

    • J. Shillito
    • Youmans J, ed. Neurological Surgery. Philadelphia: WB Saunders, 1982:224Y256 THE JOURNAL OF CRANIOFACIAL SURGERY / VOLUME 18,
    • 2007

    Noggin improves bone healing elicited by muscle stem cells expressing inducible BMP4.

    VIEW 1 EXCERPT

    Craniosynostosis. Am Fam Physician 2004;69:2863Y2870

    • H Kabbani, TS Raghuveer
    • 2004