Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement.

@article{Grace1995PostoperativeAA,
  title={Postoperative analgesia after co-administration of clonidine and morphine by the intrathecal route in patients undergoing hip replacement.},
  author={David Grace and H F Bunting and Kevin R Milligan and J P Howard Fee},
  journal={Anesthesia and analgesia},
  year={1995},
  volume={80 1},
  pages={86-91}
}
Postoperative analgesia after intrathecal co-administration of clonidine hydrochloride (75 micrograms) and morphine sulfate (0.5 mg) was compared with analgesia produced after either intrathecal morphine (0.5 mg) or 0.9% sodium chloride in 90 patients undergoing total hip replacement under bupivacaine spinal anesthesia. Patient-controlled morphine requirements were significantly reduced (P < 0.001) postoperation by both clonidine/morphine (median 5 mg/24 h) and morphine (median 7 mg/24 h… CONTINUE READING